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A sample was first utilized to the nanoACQUITY UPLC Trapping Column (Waters) using water containing 0.1% formic acid as the cell part. In addition, we integrated the appliance of secure isotope tracer methodology coupled with an OGTT that allowed us to find out the location of action (hepatic and/or peripheral) that was influenced by lysine supplementation.
Among them we recognized histone H3 lysine 27 acetylation (H3K27Ac) as a modification upregulated in CRC
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