In both proteins, the walls of the lysine-binding channel are fashioned by hydrophobic residues that engage in van der Waals interactions with the lysine aspect chain (Figure 4b,c ). Min J, Zhang X, Cheng X, Grewal SI, Xu RM: Construction of the SET domain histone lysine methyltransferase Clr4.

The exception to the rule is the DOT1 family, members of which methylate K79 within the globular region of histone H3 and which are structurally not associated to SET-area proteins four - 6 Latest work suggests that SET-area-containing proteins methylate just a few proteins in addition to histones (see later)